tTG-IgA (celiac disease)
tTG-IgA are IgA-class antibodies against tissue transglutaminase — the main screening blood test for celiac disease (autoimmune sensitivity to gluten).
| Rating | Range | What it means |
|---|---|---|
| Good | below 7 U/mL | Negative — celiac disease unlikely (with normal total IgA and a gluten-containing diet). |
| Talk to a doctor | 7 U/mL and above | Positive — celiac disease suspected; a consultation is needed for confirmation. Do NOT start a gluten-free diet beforehand. |
Why it matters
Positive with normal total IgA strongly argues for celiac disease.
If it’s low
Negative tTG-IgA (with normal total IgA and a gluten-containing diet) makes celiac disease unlikely.
If it’s high
A positive (elevated) tTG-IgA means suspicion of celiac disease; a high titer (e.g. >10× the upper limit) is a strong predictor. Confirmation with a doctor is needed (biopsy or genetics if required).
What to do
Do not interpret the result yourself. Positive → consult a doctor (gastroenterologist) for confirmation; do NOT start a gluten-free diet before that (it obscures the diagnosis). Always read together with total IgA.
Read together with
IgA (immunoglobulin A) · Ferritin · Vitamin B12
This content is for information only and is not a substitute for medical advice. Talk to your doctor about your results.
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