Liver · U/L

AST

AST is an enzyme in liver cells (and some in muscle and heart). When these cells are damaged it leaks into the blood. Together with ALT it is part of the basic liver panel — but it is less specific for the liver than ALT.

Ranges we useIFCC C-RIDL
RatingRangeWhat it means
Goodbelow 35 U/LWithin range.
Worth improving35 – 50 U/L
Talk to a doctor50 U/L and above
Source: IFCC C-RIDL · Common reference intervals for AST, ALT and GGT in serum (Ceriotti F et al., IFCC C-RIDL) · 2010 · open

Why it matters

EASL: interpret together with ALT; the ratio helps identify the cause.

If it’s low

Low AST has no clinical significance.

If it’s high

Elevated AST often accompanies liver stress (fatty liver, alcohol), but can also be muscle exertion or injury. The context (ALT, GGT, symptoms) tells where it comes from.

What to do

Read it together with ALT and GGT. If the cause is hepatic: less alcohol and sugar, fat loss, physical activity. Do not measure right after intense exercise.

Read together with

ALT · GGT · Bilirubin (total) · Alkaline phosphatase (ALP)

Part of the guide: Liver →

Articles about this marker

This content is for information only and is not a substitute for medical advice. Talk to your doctor about your results.

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